Concepts

GlaucomAI's vascular phenotypes

GlaucomAI doesn't answer “glaucoma or not”. For a patient who already has glaucoma it asks what is most likely driving it, from where the patient sits in the NTG cohort:

  • Pressure side: IOP at or above the 67th percentile (the top third).
  • Vascular side: mean perfusion pressure at or below the 33rd percentile (the bottom third), or diastolic perfusion below 50 mmHg.
  • Both give Mixed; neither gives No dominant driver.
  • Flicker, when recorded: dilation below 1.5% is impaired and confirms the vascular side; within ±0.5 of 2% is borderline and should be repeated.

The labels are hypotheses for a clinician to check, not diagnoses.

Vascular-riskMixedNo dominant driverPressure-dominant0033336767100100IOP percentile in the NTG cohort →perfusion pressure percentile →
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Label
Vascular-risk
  • mean perfusion pressure is in the lowest third of the NTG cohort
InteractiveThe same rules as the pipeline, on a map of IOP percentile against perfusion percentile.